Computer mouse freezes

I have an ACER desktop and am running Windows XP. Recently, my computer mouse has become less precise and more sporadic. I restart my computer, it works a little bit better for a few minutes, and then it eventually freezes to a stop. I've tried several mouses, and they range from working very poorly to not working at all. Any ideas?

Are they wireless or wired mice? Also try a different port. If using USB, try the PS/2 (adapter may be necessary )

Let me know how it goes..